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Research - Creating innovative therapeutic strategies for targeting immunosuppressive mechanisms in brain tumors The immunosuppressive microenvironment is one major cause of GBM therapy resistance to both standard-of-care and immunotherapy. As a hallmark of GBM, tumor-associated myeloid cells (TAMCs) represent the most predominant immune population and are a key driver of immunosuppression. Building on our expertise in cancer immunology and nanotechnology, we have engineered innovative nano-therapeutics that enable effective in vivo targeting and modulation of TAMCs in GBM models. Harnessing the functionality of TAMC by impairing their immunosuppressive activity and/or remodeling them to be tumor-eradicating cells greatly boosts anti-GBM immunity and generates an immunologically “hot” tumor. We also seek to gain insight into the crosstalk between TAMCs and adaptive immunity (i.e. effector T & B cells). https://images.squarespace-cdn.com/content/v1/62997717dd6167677f60ee9a/bd6b28fa-5fd3-43fa-ae46-3098024d2257/iStock-484324248.jpg Research - Enabling precision genetic modulation of GBM stem cells and tumor-infiltrating immune cells Despite the recognition of RNA therapeutics as the next-generation medicine, the clinical transition is still hampered by their unfavorable characteristics for in vivo application. In the context of GBM, the heterogeneity of tumor microenvironment and the existence of the blood-brain-barrier provide even greater challenges. Our group has been focused on developing non-viral nano-therapeutic platforms for effective and specific delivery of RNA therapeutics (e.g. mRNA & siRNA) towards GBM stem cells and immune cells in the tumor microenvironment. Besides RNA, we are also interested in developing highly efficient delivery system for in vivo CRISPR-Cas9 gene editing. Our platforms serve as (i) new therapeutic & vaccination approaches to potentiate anti-tumor immunity and/or overcome therapy resistance in GBM, and (ii) powerful tools to advance mechanistic studies in basic immunology & biology for identifying new therapeutic targets. https://images.squarespace-cdn.com/content/v1/62997717dd6167677f60ee9a/50bf1436-5cb6-48f8-83f2-0ff1c67a11be/iStock-1335843440.jpg Research - Understanding the interplay between standard-of-care and GBM immune microenvironment Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://pengzhang-lab.com/news daily 0.75 2026-03-13